The opening scene shows Wade Wilson, the superhero Deadpool (Ryan Reynolds) in a cab, bored in the backseat. He slides up front to chat with the cabbie, Dopinder (Karan Soni). Deadpool asks Dopinder about a picture of a girl he has in his car, and Dopinder says she was his girlfriend until he lost her to his cousin. Dopinder then takes Deadpool to the middle of a bridge, and Deadpool stiffs the man for cab fare.
Deadpool waits on top of a bridge for his targets, but first addresses the audience and jokes about fondling Wolverine’s balls to get his own movie. He then spots a group of vans arriving, and he jumps into one of the men before beating up of all the thugs in the van, causing an accident that kills other villains. Deadpool’s main target is Ajax (Ed Skrein), the man that gave him his powers and also horribly disfigured him. The vans all come crashing to the end of the bridge, where one thug’s head is slice off with a chain, and another one gets gorily splattered against a sign on the highway.
At Xavier’s School For Gifted Youngsters, Colossus (Stefan Kapicic) sees the chaos unfolding on the news and calls Negasonic Teenage Warhead (Brianna Hildebrand) to join him in getting Deadpool.
Deadpool is upset because he forgot his bag of weapons and only has 12 rounds in his gun. He counts off how many rounds with each thug he kills, accidentally missing a few shots, but he manages to kill three men with one bullet. One last thug comes at Deadpool with two knives, but Deadpool quickly skewers him. Deadpool then points out that this is a different kind of superhero movie, and that we need to go back for him to tell it properly.